Accelerated Laboratory Evolution Reveals the Influence of Replication on the GC Skew in Escherichia coli.

ABSTRACT: Most bacterial genomes display contrasting strand asymmetry in a variety of features, such as nucleotide composition and gene orientation, of the two replichores separated by the replication origin and terminus. The cause for the polarization is often attributed to mutations arising from the asymmetric replication machinery. Notably, a base compositional bias known as a GC skew is focused on as a footprint of the bacterial genome evolution driven by DNA replication. Previously, although a replication driven mutation pattern responsible for the GC skew formation or the related mathematical models have been well reported, an exact impact of the replication-related elements on the genomic structure is yet actively debated, and not confirmed experimentally. However, the GC skew formation is ve

SUBMITTER: Kono N 

PROVIDER: S-EPMC6263442 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature