Altered expression of K13 disrupts DNA replication and repair in Plasmodium falciparum.

ABSTRACT:

Background

Plasmodium falciparum exhibits resistance to the artemisinin component of the frontline antimalarial treatment Artemisinin-based Combination Therapy in South East Asia. Millions of lives will be at risk if artemisinin resistance (ART-R) spreads to Africa. Single non-synonymous mutations in the propeller region of PF3D7_1343700,"K13" are implicated in resistance. In this work, we use transcriptional profiling to characterize a laboratory-generated k13 insertional mutant previously demonstrated to have increased sensitivity to artemisinins to explore the functional role of k13.

Results

A set of RNA-seq and microarray experiments confirmed that the expression profile of k13 is specifically altered during the early ring and early trophozoite stages of the mutant intra

SUBMITTER: Gibbons J 

PROVIDER: S-EPMC6263542 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature