3.0 T relaxation time measurements of human lymph nodes in adults with and without lymphatic insufficiency: Implications for magnetic resonance lymphatic imaging.

ABSTRACT: The purpose of this work was to quantify 3.0 T (i) T₁ and T₂ relaxation times of in vivo human lymph nodes (LNs) and (ii) LN relaxometry differences between healthy LNs and LNs from patients with lymphatic insufficiency secondary to breast cancer treatment-related lymphedema (BCRL). MR relaxometry was performed over bilateral axillary regions at 3.0 T in healthy female controls (105 LNs from 20 participants) and patients with BCRL (108 LNs from 20 participants). Quantitative T₁ maps were calculated using a multi-flip-angle (20, 40, 60°) method with B₁ correction (dual-T_R method, T_R1 /T_R2  = 30/130 ms), and T₂ maps using a multi-echo (T_E  = 9-189 ms; 12 ms intervals) method. T₁ and

SUBMITTER: Crescenzi R 

PROVIDER: S-EPMC6263822 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature