Mitigating Human IAPP Amyloidogenesis In Vivo with Chiral Silica Nanoribbons.

ABSTRACT: Amyloid fibrils generally display chirality, a feature which has rarely been exploited in the development of therapeutics against amyloid diseases. This study reports, for the first time, the use of mesoscopic chiral silica nanoribbons against the in vivo amyloidogenesis of human islet amyloid polypeptide (IAPP), the peptide whose aggregation is implicated in type 2 diabetes. The thioflavin T assay and transmission electron microscopy show accelerated IAPP fibrillization through elimination of the nucleation phase and shortening of the elongation phase by the nanostructures. Coarse-grained simulations offer complementary molecular insights into the acceleration of amyloid aggregation through their nonspecific binding and directional seeding with the nanostructures. This accelerated IAPP fi

SUBMITTER: Faridi A 

PROVIDER: S-EPMC6263833 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature