Changes in body mass index, height, and weight in children during and after therapy for acute lymphoblastic leukemia.

ABSTRACT:

Background

Children with acute lymphoblastic leukemia (ALL) have an increased risk of obesity and short stature. To the authors' knowledge, data regarding patients treated on contemporary protocols without cranial irradiation are limited.

Methods

Changes in z scores for body mass index (BMI), height, and weight from the time of diagnosis to 5 years off therapy were evaluated using multivariable analysis in 372 children with ALL who were aged 2 to 18 years at the time of diagnosis and were enrolled on the St. Jude Children's Research Hospital Total XV protocol from 2000 through 2007.

Results

The percentage of overweight/obese patients increased from 25.5% at the time of diagnosis to approximately 50% during the off-therapy period. Median BMI z scores increased signific

SUBMITTER: Browne EK 

PROVIDER: S-EPMC6263845 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature