Protein variability in cerebrospinal fluid and its possible implications for neurological protein biomarker research.

ABSTRACT: Cerebrospinal fluid is investigated in biomarker studies for various neurological disorders of the central nervous system due to its proximity to the brain. Currently, only a limited number of biomarkers have been validated in independent studies. The high variability in the protein composition and protein abundance of cerebrospinal fluid between as well as within individuals might be an important reason for this phenomenon. To evaluate this possibility, we investigated the inter- and intraindividual variability in the cerebrospinal fluid proteome globally, with a specific focus on disease biomarkers described in the literature. Cerebrospinal fluid from a longitudinal study group including 12 healthy control subjects was analyzed by label-free quantification (LFQ) via LC-MS/MS. Data were q

SUBMITTER: Schilde LM 

PROVIDER: S-EPMC6264484 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature