The ontogeny of myometrial stem cells in OCT4-GFP transgenic mouse model.

ABSTRACT:

Background

Myometrium, the muscular wall of the uterus, is an active organ markedly remodeled during a woman's reproductive life, especially during pregnancy. Different studies using the 5-bromo-2'-deoxyuridine and side population methods in murine and human myometrium have suggested the presence of somatic stem cells in this tissue because of its remarkable regenerative capacity. Recently, our group has developed a surface-marker (Stro1/CD44)-specific approach to isolate and characterize myometrial somatic stem cells (SSCs) from humans and rats.

Objective

In this study, we aimed to identify and localize the putative myometrial stem cell population in the murine uterus by using the specific surface markers, Nanog/CD44.

Methods

Uteri from OCT4-GFP transgenic mice at di

SUBMITTER: Brakta S 

PROVIDER: S-EPMC6264618 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature