Airway fractal dimension predicts respiratory morbidity and mortality in COPD.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) is characterized by airway remodeling. Characterization of airway changes on computed tomography has been challenging due to the complexity of the recurring branching patterns, and this can be better measured using fractal dimensions.

Methods

We analyzed segmented airway trees of 8,135 participants enrolled in the COPDGene cohort. The fractal complexity of the segmented airway tree was measured by the Airway Fractal Dimension (AFD) using the Minkowski-Bougliand box-counting dimension. We examined associations between AFD and lung function and respiratory morbidity using multivariable regression analyses. We further estimated the extent of peribronchial emphysema (%) within 5 mm of the airway tree, as this is likely to a

SUBMITTER: Bodduluri S 

PROVIDER: S-EPMC6264725 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature