Circulating proteomic patterns in AF related left atrial remodeling indicate involvement of coagulation and complement cascade.

ABSTRACT:

Background

Left atrial (LA) electro-anatomical remodeling and diameter increase in atrial fibrillation (AF) indicates disease progression and is associated with poor therapeutic success. Furthermore, AF leads to a hypercoagulable state, which in turn promotes the development of a substrate for AF and disease progression in the experimental setting. The aim of this study was to identify pathways associated with LA remodeling in AF patients using untargeted proteomics approach.

Methods

Peripheral blood samples of 48 patients (62±10 years, 63% males, 59% persistent AF) undergoing AF catheter ablation were collected before ablation. 23 patients with left atrial low voltage areas (LVA), defined as <0.5 mV, and 25 patients without LVA were matched for age, gender and CHA2DS2-VASc

SUBMITTER: Kornej J 

PROVIDER: S-EPMC6264811 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature