Efficacy of the perfluorocarbon dodecafluoropentane as an adjunct to pre-hospital resuscitation.

ABSTRACT:

Background

Hemorrhage is the most common cause of preventable death in the pre-hospital phase in trauma, with a critical capability gap optimizing pre-hospital resuscitation in austere environments. One promising avenue is the concept of a multi-functional resuscitation fluid (MRF) that contains a blood product backbone with agents that promote clotting and enhance oxygen delivery. Oxygen therapeutics, such as hemoglobin based oxygen carriers(HBOCs) and perfluorocarbons(PFCs), may be a critical MRF component. Our purpose was to assess the efficacy of resuscitation with a PFC, dodecafluoropentane(DDFPe), compared to fresh whole blood(FWB).

Methods and findings

Forty-five swine(78±5kg) underwent splenectomy and controlled hemorrhage via femoral arterial catheter until shock ph

SUBMITTER: Bonanno AM 

PROVIDER: S-EPMC6264877 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature