Ontology highlight
ABSTRACT:
SUBMITTER: Kim J
PROVIDER: S-EPMC6265076 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Nature genetics 20181022 12
MALAT1 has previously been described as a metastasis-promoting long noncoding RNA (lncRNA). We show here, however, that targeted inactivation of the Malat1 gene in a transgenic mouse model of breast cancer, without altering the expression of its adjacent genes, promotes lung metastasis, and that this phenotype can be reversed by genetic add-back of Malat1. Similarly, knockout of MALAT1 in human breast cancer cells induces their metastatic ability, which is reversed by re-expression of Malat1. Co ...[more]