Fibroblast growth factor 21 as a circulating biomarker at various stages of colorectal carcinogenesis.

ABSTRACT:

Background

Despite evidence that inflammation and metabolism play a crucial role in colorectal carcinogenesis, there have been few studies on the association of inflammatory and metabolic protein biomarkers in various stages of colorectal carcinogenesis.

Methods

Ninety-two inflammatory and metabolic biomarkers were measured in plasma samples of participants of screening colonoscopy. Markers identified to be significantly associated with the presence of advanced colorectal neoplasia (ACN) in a discovery set (n = 204) were validated in an independent replication set (n = 422). Adjusted associations with the presence of non-advanced adenomas (NAA), advanced precancerous lesions (APL) and colorectal cancer (CRC) were quantified by multiple logistic regression.

Results

Out

SUBMITTER: Qian J 

PROVIDER: S-EPMC6265243 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature