Prolonged systemic hyperglycemia does not cause pericyte loss and permeability at the mouse blood-brain barrier.

ABSTRACT: Diabetes mellitus is associated with cognitive impairment and various central nervous system pathologies such as stroke, vascular dementia, or Alzheimer's disease. The exact pathophysiology of these conditions is poorly understood. Recent reports suggest that hyperglycemia causes cerebral microcirculation pathology and blood-brain barrier (BBB) dysfunction and leakage. The majority of these reports, however, are based on methods including in vitro BBB modeling or streptozotocin-induced diabetes in rodents, opening questions regarding the translation of the in vitro findings to the in vivo situation, and possible direct effects of streptozotocin on the brain vasculature. Here we used a genetic mouse model of hyperglycemia (Ins2^AKITA) to address whether prolonged systemic hypergly

SUBMITTER: Mae MA 

PROVIDER: S-EPMC6265246 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature