SOX9 expression decreases survival of patients with intrahepatic cholangiocarcinoma by conferring chemoresistance.

ABSTRACT:

Background

Sex-determining region Y-box (SRY-box) containing gene 9 (SOX9) expression confers cancer stem cell features. However, SOX9 function in intrahepatic cholangiocarcinoma (iCCA) is unknown. This study investigated the effects and underlying mechanisms of SOX9 in iCCA.

Methods

SOX9 expression in 59 iCCA patients was examined by immunohistochemistry. The association between SOX9 expression and clinical outcome was evaluated. Gene signature and biological functions of SOX9 in iCCA were examined in vitro.

Results

iCCA patients with high SOX9 expression had shorter survival time than those with low SOX9. In patients receiving chemotherapy, median survival time in patients with low and high levels of SOX9 were 62 and 22 months, respectively. In vitro, gemcitabine in

SUBMITTER: Yuan X 

PROVIDER: S-EPMC6265288 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature