Type 2 diabetes and risk of colorectal cancer in two large U.S. prospective cohorts.

ABSTRACT:

Background

Previous studies have shown a positive association between type 2 diabetes (T2D) and colorectal cancer (CRC) risk. However, it is uncertain whether this association differs by duration of T2D or sex. We thus investigated the associations of T2D and its duration with the risk of incident CRC.

Methods

We followed 87,523 women from the Nurses' Health Study (1980-2012) and 47,240 men from the Health Professionals Follow-up Study (1986-2012). Data on physician-diagnosed T2D was collected at baseline with a questionnaire and updated biennially. Cox regression models were used to estimate multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs).

Results

We documented 3000 CRC cases during up to 32 years of follow-up. Among men, T2D was associa

SUBMITTER: Ma Y 

PROVIDER: S-EPMC6265303 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature