Broadened immunity against influenza by vaccination with computationally designed influenza virus N1 neuraminidase constructs.

ABSTRACT: Split inactivated influenza vaccines remain one of the primary preventative strategies against severe influenza disease in the population. However, current vaccines are only effective against a limited number of matched strains. The need for broadly protective vaccines is acute due to the high mutational rate of influenza viruses and multiple strain variants in circulation at any one time. The neuraminidase (NA) glycoprotein expressed on the influenza virion surface has recently regained recognition as a valuable vaccine candidate. We sought to broaden the protection provided by NA within the N1 subtype by computationally engineering consensus NA sequences. Three NA antigens (NA5200, NA7900, NA9100) were designed based on sequence clusters encompassing three major groupings of NA sequence

SUBMITTER: Job ER 

PROVIDER: S-EPMC6265323 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature