Improving clinical diagnosis of early-stage cutaneous melanoma based on Raman spectroscopy.

ABSTRACT:

Background

Clinical diagnosis of early melanoma (Breslow thickness less than 0.8 mm) is crucial to disease-free survival. However, it is subjective and can be exceedingly difficult, leading to missed melanomas, or unnecessary excision of benign pigmented skin lesions. An objective technique is needed to improve the diagnosis of early melanoma.

Methods

We have developed a method to improve diagnosis of (thin) melanoma, based on Raman spectroscopy. In an ex vivo study in a tertiary referral (pigmented lesions) centre, high-wavenumber Raman spectra were collected from 174 freshly excised melanocytic lesions suspicious for melanoma. Measurements were performed on multiple locations within the lesions. A diagnostic model was developed and validated on an independent data set of 9

SUBMITTER: P Santos I 

PROVIDER: S-EPMC6265324 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature