Impact of ⁹⁰Y PET gradient-based tumor segmentation on voxel-level dosimetry in liver radioembolization.

ABSTRACT:

Background

The purpose was to validate ⁹⁰Y PET gradient-based tumor segmentation in phantoms and to evaluate the impact of the segmentation method on reported tumor absorbed dose (AD) and biological effective dose (BED) in ⁹⁰Y microsphere radioembolization (RE) patients. A semi-automated gradient-based method was applied to phantoms and patient tumors on the ⁹⁰Y PET with the initial bounding volume for gradient detection determined from a registered diagnostic CT or MR; this PET-based segmentation (PS) was compared with radiologist-defined morphologic segmentation (MS) on CT or MRI. AD and BED volume histogram metrics (D90, D70, mean) were calculated using both segmentations and concordance/correlations were investigated. Spatial concordance was ass

SUBMITTER: Mikell JK 

PROVIDER: S-EPMC6265358 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature