Divergent Innate and Epithelial Functions of the RNA-Binding Protein HuR in Intestinal Inflammation.

ABSTRACT: HuR is an abundant RNA-binding protein acting as a post-transcriptional regulator of many RNAs including mRNAs encoding inflammatory mediators, cytokines, death signalers and cell cycle regulators. In the context of intestinal pathologies, elevated HuR is considered to enhance the stability and the translation of pro-tumorigenic mRNAs providing the rationale for its pharmacological targeting. However, HuR also possesses specific regulatory functions for innate immunity and cytokine mRNA control which can oppose intestinal inflammation and tumor promotion. Here, we aim to identify contexts of intestinal inflammation where the innate immune and the epithelial functions of HuR converge or diverge. To address this, we use a disease-oriented phenotypic approach using mice lacking HuR either in

SUBMITTER: Christodoulou-Vafeiadou E 

PROVIDER: S-EPMC6265365 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature