Patterns of post-operative irradiation in breast cancer patients submitted to neoadjuvant chemotherapy.

ABSTRACT:

Background/aim

Post-operative radiation therapy (PORT) is associated with improvement in loco-regional control and survival rates in early breast cancer. However, the evidence of benefit in patients after treatment with neoadjuvant chemotherapy (NAC) is poor. We aimed to assess the impact of the type of surgery in the PORT plan and the role of the PORT fields in clinical outcomes in breast cancer patients who had undergone NAC followed by surgery.

Materials and methods

We performed a retrospective analysis of all non-metastatic breast cancer patients treated between 2008 and 2014 at our institution who had received NAC and PORT.

Results

A total of 528 women were included of whom 396 were submitted to mastectomy or nipple-sparing/skin-sparing mastectomy. Most (92.8%) o

SUBMITTER: Lima KMLB 

PROVIDER: S-EPMC6265518 | biostudies-literature | 2019 Jan-Feb

REPOSITORIES: biostudies-literature