Synergistic effect of ribavirin and vaccine for protection during early infection stage of foot-and-mouth disease.

ABSTRACT: In many countries, vaccines are used for the prevention of foot-and-mouth disease (FMD). However, because there is no protection against FMD immediately after vaccination, research and development on antiviral agents is being conducted to induce protection until immunological competence is produced. This study tested whether well-known chemicals used as RNA virus treatment agents had inhibitory effects on FMD viruses (FMDVs) and demonstrated that ribavirin showed antiviral effects against FMDV in vitro/in vivo. In addition, it was observed that combining the administration of the antiviral agents orally and complementary therapy with vaccines synergistically enhanced antiviral activity and preserved the survival rate and body weight in the experimental animals. Antiviral agents mixe

SUBMITTER: Choi JH 

PROVIDER: S-EPMC6265586 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature