A phase 2 study of ruxolitinib in combination with azacitidine in patients with myelofibrosis.

ABSTRACT: Ruxolitinib (RUX)-based combinations may provide benefit for patients with myelofibrosis (MF). In this open-label, nonrandomized, prospective phase 2 study, patients with MF initially received RUX twice per day continuously in 28-day cycles for the first 3 cycles. Azacitidine (AZA) 25 mg/m² (days 1-5) was added starting with cycle 4 and could be subsequently increased to 75 mg/m² (days 1-5). Forty-six patients were enrolled with a median follow-up of 28 months (range, 4-50+ months). An International Working Group for Myelofibrosis Research and Treatment (IWG-MRT) response was achieved in 33 patients (72%), with a median time to response of 1.8 months (range, 0.7-19.0 months). One-fourth (7 of 33) of the IWG-MRT responses occurred after the addition of AZA. A reduction

SUBMITTER: Masarova L 

PROVIDER: S-EPMC6265645 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature