HCV-Specific T Cell Responses During and After Chronic HCV Infection.

ABSTRACT: Hepatitis C virus (HCV)-specific T cell responses are closely linked to the clinical course of infection. While T cell responses in self-limiting infection are typically broad and multi-specific, they display several distinct features of functional impairment in the chronic phase. Moreover, HCV readily adapts to immune pressure by developing escape mutations within epitopes targeted by T cells. Much of our current knowledge on HCV-specific T cell responses has been gathered under the assumption that this might eventually pave the way for a therapeutic vaccine. However, with the development of highly efficient direct acting antivirals (DAAs), there is less interest in the development of a therapeutic vaccine for HCV and the scope of T cell research has shifted. Indeed, the possibility to ra

SUBMITTER: Luxenburger H 

PROVIDER: S-EPMC6265781 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature