The Natural Flavonoid Compound Deguelin Inhibits HCMV Lytic Replication within Fibroblasts.

ABSTRACT: Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus for which there is no vaccine or cure. This viral infection, once acquired, is life-long, residing latently in hematopoietic cells. However, latently infected individuals with weakened immune systems often undergo HCMV reactivation, which can cause serious complications in immunosuppressed and immunocompromised patients. Current anti-viral therapies target late stages of viral replication, and are often met with therapeutic resistance, necessitating the development of novel therapeutics. In this current study, we identified a naturally-occurring flavonoid compound, deguelin, which inhibits HCMV lytic replication. Our findings reveal that nanomolar concentrations of deguelin significantly suppress the production of the infectious viru

SUBMITTER: Nukui M 

PROVIDER: S-EPMC6265796 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature