Whole Genome Transcriptome Analysis of the Association between Obesity and Triple-Negative Breast Cancer in Caucasian Women.

ABSTRACT:

Background

Triple-negative breast cancer (TNBC) is the most aggressive form of breast cancer, with poor outcomes. The molecular basis of TNBC remains poorly understood. The objective of this exploratory study was to investigate the association between obesity and TNBC in premenopausal and postmenopausal Caucasian women using transcription profiling.

Methods

We compared gene expression levels of tumor samples drawn from normal weight, overweight, and obese pre and postmenopausal women diagnosed with TNBC. We performed hierarchical clustering to assess similarity in patterns of gene expression profiles, and conducted network and pathway analysis to identify molecular networks and biological pathways.

Results

We discovered gene signatures distinguishing normal weight fro

SUBMITTER: Mamidi TKK 

PROVIDER: S-EPMC6265882 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature