Potential Antiviral Xanthones from a Coastal Saline Soil Fungus Aspergillus iizukae.

ABSTRACT: Five new (1⁻5) and two known xanthones (6 and 7), one of the latter (6) obtained for the first time as a natural product, together with three known anthraquinones, questin, penipurdin A, and questinol, were isolated from the coastal saline soil-derived Aspergillus iizukae by application of an OSMAC (one strain many compounds) approach. Their structures were determined by interpretation of nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectroscopy (HRESIMS) data, as well as comparison of these data with those of related known compounds. Antiviral activity of xanthones 1-7 was evaluated through the cytopathic effect (CPE) inhibition assay, and compound 2 exhibited distinctly strong activity tow

SUBMITTER: Kang HH 

PROVIDER: S-EPMC6265927 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature