Molecular Mechanisms Regulating Organ-Specific Metastases in Epithelial Ovarian Carcinoma.

ABSTRACT: Epithelial ovarian carcinoma is the most predominant type of ovarian carcinoma, the deadliest gynecologic malignancy. It is typically diagnosed late when the cancer has already metastasized. Transcoelomic metastasis is the most predominant mechanism of dissemination from epithelial ovarian carcinoma, although both hematogenously and lymphogenously spread metastases also occur. In this review, we describe molecular mechanisms known to regulate organ-specific metastasis from epithelial ovarian carcinoma. We begin by discussing the sites colonized by metastatic ovarian carcinoma and rank them in the order of prevalence. Next, we review the mechanisms regulating the transcoelomic metastasis. Within this chapter, we specifically focus on the mechanisms that were demonstrated to regulate periton

SUBMITTER: Barbolina MV 

PROVIDER: S-EPMC6266311 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature