Bioinformatics and Functional Assessment of Toxin-Antitoxin Systems in Staphylococcus aureus.

ABSTRACT: Staphylococcus aureus is a nosocomial pathogen that can cause chronic to persistent infections. Among different mediators of pathogenesis, toxin-antitoxin (TA) systems are emerging as the most prominent. These systems are frequently studied in Escherichia coli and Mycobacterial species but rarely explored in S. aureus. In the present study, we thoroughly analyzed the S. aureus genome and screened all possible TA systems using the Rasta bacteria and toxin-antitoxin database. We further searched E. coli and Mycobacterial TA homologs and selected 67 TA loci as putative TA systems in S. aureus. The host inhibition of growth (HigBA) TA family was predominantly detected in S. aureus. In addition, we detected seven pathogenicity islan

SUBMITTER: Habib G 

PROVIDER: S-EPMC6266405 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature