Improvement of renal function estimation equations for elderly Japanese people.

ABSTRACT:

Background and aim

The Cockcroft-Gault (C-G) equation for estimation of creatinine clearance (CCr) is still used in a clinical setting for drug dosage adjustment. Because differences between measured and estimated CCr values have been reported, particularly for Japanese elderly people, the aim of this study was to improve the accuracy of CCr estimation equations, such as C-G and Orita-Horio, by fitting to newly obtained data. Also, glomerular filtration rate (GFR) estimation equations, such as the Modification of Diet in Renal Disease (MDRD), the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), and the eGFR equation for Japanese people, were studied to compare with measured CCr.

Method

Data from 313 subjects over the age of 40 years with laboratory data available

SUBMITTER: Kaburaki S 

PROVIDER: S-EPMC6266418 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature