Evolution of Codon Usage Bias in Henipaviruses Is Governed by Natural Selection and Is Host-Specific.

ABSTRACT: Hendra virus (HeV) and Nipah virus (NiV) are among a group of emerging bat-borne paramyxoviruses that have crossed their species-barrier several times by infecting several hosts with a high fatality rate in human beings. Despite the fatal nature of their infection, a comprehensive study to explore their evolution and adaptation in different hosts is lacking. A study of codon usage patterns in henipaviruses may provide some fruitful insight into their evolutionary processes of synonymous codon usage and host-adapted evolution. Here, we performed a systematic evolutionary and codon usage bias analysis of henipaviruses. We found a low codon usage bias in the coding sequences of henipaviruses and that natural selection, mutation pressure, and nucleotide compositions shapes the co

SUBMITTER: Kumar N 

PROVIDER: S-EPMC6266499 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature