Limonoids Containing a C₁⁻O⁻C29 Moiety: Isolation, Structural Modification, and Antiviral Activity.

ABSTRACT: Five new limonoids named thaigranatins A⁻E (1⁻5), containing a C₁⁻O⁻C29 moiety, were isolated from seeds of the Thai Xylocarpus granatum, collected at the mangrove swamp of Trang Province, together with the known limonoid, granatumin L (6). The structures of these compounds were established by HR-ESIMS and extensive NMR spectroscopic data. The absolute configuration of 1 was unequivocally determined by single-crystal X-ray diffraction analysis, conducted with Cu Kα radiation; whereas that of 2 or 6 was established to be the same as that of 1 by the similarity of their electronic circular dichroism (ECD) spectra. In view of the marked antiviral activity of 6, its structure was modified via hydrolysis with alkaline KOH, esterification with diazomethane and various organic acids, and oximizat

SUBMITTER: Ren JL 

PROVIDER: S-EPMC6266505 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature