Automated Knowledge-Based Intensity-Modulated Proton Planning: An International Multicenter Benchmarking Study.

ABSTRACT: Background: Radiotherapy treatment planning is increasingly automated and knowledge-based planning has been shown to match and sometimes improve upon manual clinical plans, with increased consistency and efficiency. In this study, we benchmarked a novel prototype knowledge-based intensity-modulated proton therapy (IMPT) planning solution, against three international proton centers. Methods: A model library was constructed, comprising 50 head and neck cancer (HNC) manual IMPT plans from a single center. Three external-centers each provided seven manual benchmark IMPT plans. A knowledge-based plan (KBP) using a standard beam arrangement for each patient was compared with the benchmark plan on the basis of planning target volume (PTV) coverage and homogeneity and mean organ-at-r

SUBMITTER: Delaney AR 

PROVIDER: S-EPMC6266684 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature