Multi-omic analysis of signalling factors in inflammatory comorbidities.

ABSTRACT:

Background

Inflammation is a core element of many different, systemic and chronic diseases that usually involve an important autoimmune component. The clinical phase of inflammatory diseases is often the culmination of a long series of pathologic events that started years before. The systemic characteristics and related mechanisms could be investigated through the multi-omic comparative analysis of many inflammatory diseases. Therefore, it is important to use molecular data to study the genesis of the diseases. Here we propose a new methodology to study the relationships between inflammatory diseases and signalling molecules whose dysregulation at molecular levels could lead to systemic pathological events observed in inflammatory diseases.

Results

We first perform an explor

SUBMITTER: Xiao H 

PROVIDER: S-EPMC6266935 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature