Mood Disorders and Gluten: It's Not All in Your Mind! A Systematic Review with Meta-Analysis.

ABSTRACT: Gluten elimination may represent an effective treatment strategy for mood disorders in individuals with gluten-related disorders. However, the directionality of the relationship remains unclear. We performed a systematic review of prospective studies for effects of gluten on mood symptoms in patients with or without gluten-related disorders. Six electronic databases (CINAHL, PsycINFO, Medline, Web of Science, Scopus and Cochrane Library) were searched, from inception to 8 August 2018, for prospective studies published in English. Meta-analyses with random-effects were performed. Three randomised-controlled trials and 10 longitudinal studies comprising 1139 participants fit the inclusion criteria. A gluten-free diet (GFD) significantly improved pooled depressive symptom scores in GFD-treate

SUBMITTER: Busby E 

PROVIDER: S-EPMC6266949 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature