Oxysterols from a Marine Sponge Inflatella sp. and Their Action in 6-Hydroxydopamine-Induced Cell Model of Parkinson's Disease.

ABSTRACT: Four new oxysterols 1⁻4 along with previously known oxygenated sterols 5⁻14 were isolated from the sponge Inflatella sp., collected from the Sea of Okhotsk. Structures of 1⁻4 were elucidated by the detailed NMR spectroscopic and mass-spectrometric analyses as well as by comparison of the corresponding experimental data with those reported in literature. The influence of compounds 1⁻14 on the viability of neuronal Neuro2a cells treated by 6-hydroxydopamine and reactive oxygen species (ROS) formation in these cells was investigated.

SUBMITTER: Kolesnikova SA 

PROVIDER: S-EPMC6267020 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature