2'-5'-Oligoadenylate synthetase 1 polymorphisms are associated with tuberculosis: a case-control study.

ABSTRACT:

Background

2'-5'-Oligoadenylate synthetase 1 (OAS1) plays an important role in inflammatory immune reactions. OAS1 polymorphisms have been associated with increased susceptibility to various diseases. We investigated the association of polymorphisms in OAS1 with tuberculosis (TB).

Methods

A total of 1215 TB cases and 1114 healthy controls were enrolled from two independent studies. Genotyping was conducted using the improved multiplex ligase detection reaction (iMLDR) method. Associations between OAS1 polymorphisms (rs2240190, rs1131454, 10,774,671 and 11,066,453) and TB risk were established based on distributions of allelic frequencies using different genetic models.

Results

Significant association was observed between rs10774671, rs1131454 and TB. In the initial st

SUBMITTER: Wu S 

PROVIDER: S-EPMC6267069 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature