Genomics of neonatal sepsis: has-miR-150 targeting BCL11B functions in disease progression.

ABSTRACT:

Background

Neonatal sepsis is an inflammatory systemic syndrome, which is a major cause of morbidity and mortality in premature infants. We analyzed the expression profile data of E-MTAB-4785 to reveal the pathogenesis of the disease.

Methods

The expression profile dataset E-MTAB-4785, which contained 17 sepsis samples and 19 normal samples, was obtained from the ArrayExpress database. The differentially expressed genes (DEGs) were analyzed by the Bayesian testing method in limma package. Based on the DAVID online tool, enrichment analysis was conducted for the DEGs. Using STRING database and Cytoscape software, protein-protein interaction (PPI) network and module analyses were performed. Besides, transcription factor (TF)-DEG regulatory network was also constructed by Cytos

SUBMITTER: Huang L 

PROVIDER: S-EPMC6267077 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature