Causal Relationship Between Anti-TPO IgE and Chronic Urticaria by In Vitro and In Vivo Tests.

ABSTRACT:

Purpose

Immunoglobulin (Ig) E autoantibodies against thyroid antigens such as thyroid peroxidase (TPO) have been demonstrated in chronic spontaneous urticaria (CSU) patients in higher frequency than healthy subjects. However, if these IgE autoantibodies can trigger urticaria is still a matter of study. The aim of this study was to investigate the relationship between concomitant IgE autoantibodies against thyroid antigens in CSU.

Methods

Patients with CSU, healthy subjects and patients with autoimmune thyroid disease (ATD) were recruited. Total IgE and specific anti-TPO IgE and IgG were assessed in all subjects. The basophil activation test and skin tests with TPO were performed to demonstrate whether this antigen could selectively induce urticaria reaction in subjects with

SUBMITTER: Sanchez J 

PROVIDER: S-EPMC6267185 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature