Expression and glucocorticoid-dependent regulation of the stress-inducible protein DRR1 in the mouse adult brain.

ABSTRACT: Identifying molecular targets that are able to buffer the consequences of stress and therefore restore brain homeostasis is essential to develop treatments for stress-related disorders. Down-regulated in renal cell carcinoma 1 (DRR1) is a unique stress-induced protein in the brain and has been recently proposed to modulate stress resilience. Interestingly, DRR1 shows a prominent expression in the limbic system of the adult mouse. Here, we analyzed the neuroanatomical and cellular expression patterns of DRR1 in the adult mouse brain using in situ hybridization, immunofluorescence and Western blot. Abundant expression of DRR1 mRNA and protein was confirmed in the adult mouse brain with pronounced differences between distinct brain regions. The strongest DRR1 signal was detected in the neocor

SUBMITTER: Masana M 

PROVIDER: S-EPMC6267262 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature