Can microRNA profiles predict corticosteroid responsiveness in childhood nephrotic syndrome? A study protocol.

ABSTRACT:

Introduction

In last few years, several studies have revealed the remarkable stability of extracellular microRNAs (miRNAs) circulating in the blood or excreted in the urine and underscored their key importance as biomarkers of certain diseases. Since miRNA in urinary sediment is relatively stable and easily quantified, it has the potential to be developed as a biomarker for disease diagnosis and monitoring. Identification of serum and urinary levels of certain miRNAs may assist in the diagnosis and assessment of disease activity in patients with nephrotic syndrome (NS). The global expression profile of miRNAs in childhood NS in Indian population remains unknown. Hence, further research is warranted in this area. This study seeks to prospectively evaluate whether a multipronged mult

SUBMITTER: Patnaik SK 

PROVIDER: S-EPMC6267312 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature