Calcium Independent Effect of Orai1 and STIM1 in Non-Hodgkin B Cell Lymphoma Dissemination.

ABSTRACT: Ca²⁺ release-activated Ca²⁺ channels, composed of Orai1 and STIM1 (stromal interaction molecule 1) proteins, are the main Ca²⁺ entry mechanism in lymphocytes. Their role in cell migration and metastasis is demonstrated in solid cancers but it remains elusive in malignant hemopathies. Diffuse large B cell lymphoma (DLBCL) is characterized by the dissemination of neoplastic B cells throughout the organism which is under the control of chemokines such as Stromal Derived Factor 1 (SDF-1) and its receptor CXCR4. CXCR4 activation triggers a complex intracellular signaling including an increase in intracellular Ca²⁺ concentration whose role is still unclear. Using pharmacological and genetic approaches, we revealed that STIM1 and Orai1 were responsible

SUBMITTER: Latour S 

PROVIDER: S-EPMC6267368 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature