How high resolution 3-dimensional imaging changes our understanding of postnatal lung development.

ABSTRACT: During the last 10 + years biologically and clinically significant questions about postnatal lung development could be answered due to the application of modern cutting-edge microscopic and quantitative histological techniques. These are in particular synchrotron radiation based X-ray tomographic microscopy (SRXTM), but also ³Helium Magnetic Resonance Imaging, as well as the stereological estimation of the number of alveoli and the length of the free septal edge. First, the most important new finding may be the following: alveolarization of the lung does not cease after the maturation of the alveolar microvasculature but continues until young adulthood and, even more important, maybe reactivated lifelong if needed to rescue structural damages of the lungs. Second, the pulmonary

SUBMITTER: Schittny JC 

PROVIDER: S-EPMC6267404 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature