Gut microbiota, dietary intakes and intestinal permeability reflected by serum zonulin in women.

ABSTRACT:

Purpose

Increased gut permeability causes the trespass of antigens into the blood stream which leads to inflammation. Gut permeability reflected by serum zonulin and diversity of the gut microbiome were investigated in this cross-sectional study involving female study participants with different activity and BMI levels.

Methods

102 women were included (BMI range 13.24-46.89 kg m^-2): Anorexia nervosa patients (n = 17), athletes (n = 20), normal weight (n = 25), overweight (n = 21) and obese women (n = 19). DNA was extracted from stool samples and subjected to 16S rRNA gene analysis (V1-V2). Quantitative Insights Into Microbial Ecology (QIIME) was used to analyze data. Zonulin was measured with ELISA. Nutrient intake was assessed by repeated 24-h dietary recalls. We

SUBMITTER: Morkl S 

PROVIDER: S-EPMC6267414 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature