CRISPRStudio: A User-Friendly Software for Rapid CRISPR Array Visualization.

ABSTRACT: The CRISPR-Cas system biologically serves as an adaptive defense mechanism against phages. However, there is growing interest in exploiting the hypervariable nature of the CRISPR locus, often of viral origin, for microbial typing and tracking. Moreover, the spacer content of any given strain provides a phage resistance profile. Large-scale CRISPR typing studies require an efficient method for showcasing CRISPR array similarities across multiple isolates. Historically, CRISPR arrays found in microbes have been represented by colored shapes based on nucleotide sequence identity and, while this approach is now routinely used, only scarce computational resources are available to automate the process, making it very time-consuming for large datasets. To alleviate this tedious task, we introduce

SUBMITTER: Dion MB 

PROVIDER: S-EPMC6267562 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature