The effect of anesthetic technique on µ-opioid receptor expression and immune cell infiltration in breast cancer.

ABSTRACT:

Background

Clinical histological studies demonstrate that the distribution of natural killer (NK) cells, other immune cells and μ-opioid receptors (MOR) within cancer tissue can predict cancer prognosis. No clinical study has evaluated whether anesthetic technique influences immune cell and MOR expression within human breast cancer.

Methods

Excised preoperative biopsies and intraoperative breast cancer specimens from 20 patients randomly chosen from patients previously enrolled in an ongoing, prospective, randomized trial (NCT00418457) investigating the effect of anesthetic technique on long-term breast cancer outcome were immunohistochemically stained and microscopically examined by two independent investigators, masked to randomization, to quantify MOR and immune cell infi

SUBMITTER: Levins KJ 

PROVIDER: S-EPMC6267716 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature