NLRP6, decreased in gastric cancer, suppresses tumorigenicity of gastric cancer cells.

ABSTRACT:

Background

Helicobacter pylori (H. pylori) infection has been regarded as a main risk factor for gastric cancer. Nod-like receptor pyrin domain-containing protein 6 (NLRP6), a component of inflammasome, has been linked to colorectal tumorigenesis. Here, we aimed to evaluate NLRP6 expression profile and functions in gastric cancer.

Materials and methods

We examined NLRP6 expression in gastric cancer and adjacent normal gastric tissues. The biological functions and mechanism of NLRP6 overexpression in gastric cancer cells were investigated.

Results

Downregulated NLRP6 expression in human gastric cancer significantly correlated with H. pylori infection, tumor size, TNM stage, lymph node metastasis, and overall survival. NLRP6 overexpression in gastri

SUBMITTER: Wang Q 

PROVIDER: S-EPMC6267737 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature