Genetic associations in community context: a mixed model approach identifies a functional variant in the RBP4 gene associated with HDL-C dyslipidemia.

ABSTRACT:

Background

The objective of this study was to examine individual and community factors that influence high-density lipoprotein cholesterol (HDL-C) dyslipidemia in Newfoundland and Labrador (NL), a genetically isolated population in Canada with a high prevalence of HDL-C dyslipidemia.

Methods

First, a group of single nucleotide polymorphisms from 10 metabolic trait candidate genes was tested using a multivariate logistic regression model. The significant SNPs were entered into the second phase, where a mixed logistic model incorporated the community disease risk factors together with the individual factors as the fixed part of the model and the geographic region as a random effect.

Results

Analysis of 1489 subjects (26.9% HDL-C dyslipidemia) identified rs3758539, a non

SUBMITTER: Aref-Eshghi E 

PROVIDER: S-EPMC6267790 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature