Sample size calculation in multi-centre clinical trials.

ABSTRACT:

Background

Multi-centre randomized controlled clinical trials play an important role in modern evidence-based medicine. Advantages of collecting data from more than one site are numerous, including accelerated recruitment and increased generalisability of results. Mixed models can be applied to account for potential clustering in the data, in particular when many small centres contribute patients to the study. Previously proposed methods on sample size calculation for mixed models only considered balanced treatment allocations which is an unlikely outcome in practice if block randomisation with reasonable choices of block length is used.

Methods

We propose a sample size determination procedure for multi-centre trials comparing two treatment groups for a continuous outcome, m

SUBMITTER: Harden M 

PROVIDER: S-EPMC6267841 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature