A pilot study of stereotactic body radiation therapy (SBRT) after surgery for stage III non-small cell lung cancer.

ABSTRACT:

Background

Standard therapy for stage III non-small cell lung cancer with chemotherapy and conventional radiation has suboptimal outcomes. We hypothesized that a combination of surgery followed by stereotactic body radiation therapy (SBRT) would be a safe alternative.

Methods

Patients with stage IIIA (multistation N2) or IIIB non-small cell lung cancer were enrolled from March 2013 to December 2015. The protocol included transcervical extended mediastinal lymphadenectomy (TEMLA) followed by surgical resection, 10 Gy SBRT directed to the involved mediastinum/hilar stations and/or positive surgical margins, and adjuvant systemic therapy. Patients not suitable for anatomic lung resection were treated with 30 Gy to the primary tumor. The primary efficacy end-point was the propor

SUBMITTER: Singh AK 

PROVIDER: S-EPMC6267846 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature