IL-17A contributes to perioperative neurocognitive disorders through blood-brain barrier disruption in aged mice.

ABSTRACT:

Background

Perioperative neurocognitive disorders (PND) occur frequently after surgery, especially in aged patients. Surgery-induced neuroinflammation and blood-brain barrier (BBB) dysfunction play a crucial role in the pathogenesis of PND. Interleukin-17A (IL-17A) increases after surgical stress and will be involved in BBB dysfunction. However, the effect of IL-17A on BBB function during PND remains poorly understood.

Methods

Male wild-type C57BL/6J mice (15 months old) received tibial fracture surgery and fixation to establish the PND model. All the mice were injected intraperitoneally with an IL-17A-neutralizing antibody (Abs) or isotype-control Abs 30 min before tibial fracture surgery. Animal behaviour tests conducted 24 h after surgery included the contextual fear cond

SUBMITTER: Ni P 

PROVIDER: S-EPMC6267879 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature